Sharing Our BioRxiv Preprint by Sidney Williams

Excited to share our BioRxiv preprint "Hippocampal Activity Dynamics During Contextual Reward Association in Virtual Reality Place Conditioning", in which we used two-photon calcium imaging to examine the neuronal representation of context as animals developed morphine-paired environmental associations using a virtual reality conditioned place preference (VR-CPP) paradigm. We found increased activity in rewarded contexts following real-time operant conditioning with water rewards, but not after Mor-CPP training, suggesting different neural encoding mechanisms for natural reinforcers and morphine.

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Moron Lab