Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.

Bavley CCRice RCFischer DKFakira AKByrne MKosovsky MRizzo BKDel Prete DAlaedini AMorón JAHiggins JJD'Adamio LRajadhyaksha AM(2018)

Journal of Neuroscience

The dynamic interaction between pain and opioid misuse.

Wilson-Poe AR, Morón JA (2017)

British Journal of Pharmacology 

Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.

Cabañero DIrie TCelorrio MTrousdale COwens DMVirley DAlbrecht PJCaterina MJRice FLMorón JA (2016)

Pain Reports 


A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System.

Massaly N, Morón JA, Al-Hasani R (2016) 

Frontiers in neuroscience, 10():480.

Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.

Cabanero D, Irie T, Celorrio M, Trousdale C, Owens DM, Virley D, Albrecht PH, Caterina MJ, Rice FL, Moron JA (2016) 

PAIN Reports

Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons.

Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA (2016) 

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology


Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. (2016) 

Science signaling, 9(410):ra5.

Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors.

Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM, Bruchas MR, Morón JA (2015) 

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(35):12217-31.

Evidence of CNIH3 involvement in opioid dependence.

Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH.,Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW. (2015) 

Molecular psychiatry


Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C (2015) 

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7):1609-18.

In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.

Hipólito L, Fakira AK, Cabañero D, Blandón R, Carlton SM, Morón JA, Melyan Z (2015) 

Pain, 156(5):849-58.

Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.

Beaudry H, Gendron L, Morón JA (2015)

European journal of neuroscience, 41(7):901--7.

Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.

Fakira AK, Portugal GS, Carusillo B, Melyan Z, Morón JA (2014) 

Biological psychiatry, 75(2):105-14.


Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference.

Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Morón JA (2014) 

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(2):527-38.

Systemic morphine treatment induces changes in firing patterns and responses of nociceptive afferent fibers in mouse glabrous skin.

Hogan D, Baker AL, Morón JA, Carlton SM (2013) 

Pain, 154(11):2297-309.

Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.

Cabañero D, Baker A, Zhou S, Hargett GL, Irie T, Xia Y, Beaudry H, Gendron L, Melyan Z, Carlton SM (2013) 

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(8):1472-84.

Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine.

Xia Y, Portugal GS, Fakira AK, Melyan Z, Neve R, Lee HT, Russo SJ, Liu J, Morón JA (2011) 

The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(45):16279-91.

Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse.

Billa SK, Xia Y, Morón JA (2010) 

The European journal of neuroscience, 32(4):625-31.

Increased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration.

Billa SK, Liu J, Bjorklund NL, Sinha N, Fu Y, Shinnick-Gallagher P, Morón JA (2010) 

Molecular pharmacology, 77(5):874-83.

Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses.

Billa SK, Sinha N, Rudrabhatla SR, Morón JA (2009) 

The European journal of neuroscience, 29(1):55-64.