A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction.

Bechara A, Berridge DC, Bickel WK, Moron JA, Williams SB, Stein JS

Psychol Sci Public Interest. October 20, 2019.

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Cornichon Homolog-3 (CNIH3) Modulates Spatial Memory in Female Mice

Hannah E Frye, Sidney B Williams, Christopher R Trousdale, Elliot C Nelson, Joseph D Dougherty, and Jose A Moron.

BioRxiv. August 5, 2019.

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Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System

Nicolas Massaly; Bryan A. Copits; Adrianne R. Wilson-Poe; Lucia Hipólito; Tamara Markovic; Hye Jean Yoon; Shiwei Liu; Marie C. Walicki; Dionnet L. Bhatti; Sunil Sirohi; Amanda Klaas; Brendan M. Walker; Rachael Neve; Catherine M. Cahill; Kooresh I. Shoghi; Robert W. Gereau; Jordan G. McCall; Ream Al-Hasani; Michael R. Bruchas; Jose A. Morón

Neuron. March 13, 2019

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Hippocampal Activity Dynamics During Contextual Reward Association in Virtual Reality Place Conditioning.

Sidney B Williams, Moises Arriaga, William W Post, Akshata A Korgaonkar, Jose A Moron, Edward B. Han

BioRxiv. February 10, 2019.

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Opioid receptors inhibit the spinal AMPA receptor Ca2+ permeability that mediates latent pain sensitization.

Taylor BK, Sinha GP, Donahue RR, Grachen CM, Morón JA, Doolen S

Experimental Neurology. 2019 Apr;314:58-66.

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Pain And Opioid Systems, Implications In The Opioid Epidemic.

Nicolas Massaly, Jose A Morón

Current Opinion in Behavioral Sciences Volume 26, April 2019, Pages 69-74

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Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.

Bavley CC, Rice RC, Fischer DK, Fakira AK, Byrne M, Kosovsky M, Rizzo BK, Del Prete D, Alaedini A, Morón JA, Higgins JJ, D'Adamio L, Rajadhyaksha AM

Journal of Neuroscience. 2018 Mar 14;38(11):2780-2795.

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The dynamic interaction between pain and opioid misuse.

Wilson-Poe AR, Morón JA

British Journal of Pharmacology. 2018 Jul;175(14):2770-2777.

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Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.

Cabañero D, Irie T, Celorrio M, Trousdale C, Owens DM, Virley D, Albrecht PJ, Caterina MJ, Rice FL, Morón JA

PAIN Reports. 2016 Sep;1(3). pii: e573.

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A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System.

Massaly N, Morón JA, Al-Hasani R

Frontiers in Neuroscience. 2016 Nov 7;10:480

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Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.

Cabanero D, Irie T, Celorrio M, Trousdale C, Owens DM, Virley D, Albrecht PH, Caterina MJ, Rice FL, Moron JA

PAIN Reports. September 2016, Volume 1, Issue 3, p. e573.

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Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons.

Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA 

Neuropsychopharmacology. 2016 Oct;41(11):2668-78.

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Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J 

Science Signaling. 2016 Jan 12;9(410):ra5.

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Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors.

Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM, Bruchas MR, Morón JA

The Journal of Neuroscience. 2015 Sep 2;35(35):12217-31.

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Evidence of CNIH3 involvement in opioid dependence.

Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH.,Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW

Molecular Psychiatry. 2016 May;21(5):608-14.

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Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C

Neuropsychopharmacology. 2015 Jun;40(7):1609-18.

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In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.

Hipólito L, Fakira AK, Cabañero D, Blandón R, Carlton SM, Morón JA, Melyan Z

PAIN. 2015 May;156(5):849-58.

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Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.

Beaudry H, Gendron L, Morón JA

European Journal of Neuroscience. 2015 Apr;41(7):901-7.

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Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.

Fakira AK, Portugal GS, Carusillo B, Melyan Z, Morón JA

Biological psychiatry. 2014 Jan 15;75(2):105-14.

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Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference.

Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Morón JA

The Journal of Neuroscience. 2014 Jan 8;34(2):527-38. 

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Systemic morphine treatment induces changes in firing patterns and responses of nociceptive afferent fibers in mouse glabrous skin.

Hogan D, Baker AL, Morón JA, Carlton SM (2013) 

PAIN, 154(11):2297-309.

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Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.

Cabañero D, Baker A, Zhou S, Hargett GL, Irie T, Xia Y, Beaudry H, Gendron L, Melyan Z, Carlton SM (2013) 

Neuropsychopharmacology, 38(8):1472-84.

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Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine.

Xia Y, Portugal GS, Fakira AK, Melyan Z, Neve R, Lee HT, Russo SJ, Liu J, Morón JA (2011) 

The Journal of Neuroscience, 31(45):16279-91.

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Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse.

Billa SK, Xia Y, Morón JA (2010) 

The European Journal of Neuroscience, 32(4):625-31.

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Increased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration.

Billa SK, Liu J, Bjorklund NL, Sinha N, Fu Y, Shinnick-Gallagher P, Morón JA (2010) 

Molecular Pharmacology, 77(5):874-83.

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Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses.

Billa SK, Sinha N, Rudrabhatla SR, Morón JA (2009) 

The European Journal of Neuroscience, 29(1):55-64.

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